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Therapeutic Specialties

AISER specializes in key therapeutic areas. This focus allows us to provide scientific expertise, operational excellence, and close alignment with our clients' goals.

Ramaz Miraishvili Research Fellow

Almost All Articles On Cancer Prognostic Markers Report Statistically Significant Results

Almost All Articles On Cancer Prognostic Markers Report Statistically Significant Results: Commentary from F1000

Kyzas PA, Denaxa-Kyza D, Ioannidis JP
Eur J Cancer 2007 Nov 43(17):2559-79

Commentary from Faculty Member Willi Sauerbrei
This is a landmark review illustrating the severity of reporting bias in prognostic marker research.

Read more: Almost All Articles On Cancer Prognostic Markers Report Statistically Significant Results

Calcitonin Measurement in the Evaluation of Thyroid Nodules in the United States

Calcitonin Measurement in the Evaluation of Thyroid Nodules in the United States: Commentary from F1000


Cheung K, Roman SA, Wang TS, Walker HD, Sosa JA

J Clin Endocrinol Metab 2008 Jun 93(6):2173-80


Commentary from Faculty Member Furio Pacini with Stefania Marchisotta
Changes Clinical Practice: Physicians in the USA should screen patients with thyroid nodules using serum CT measurement in their clinical practice.

Read more: Calcitonin Measurement in the Evaluation of Thyroid Nodules in the United States

Eradicating H. pylori Reduces Risk for Gastric Cancer Recurrence

A Japanese study of patients with early gastric cancer shows that eradicating the bacteria Helicobacter pylori after surgery greatly reduces the risk of gastric cancer developing again. This adds to data from previous studies showing a causal relation between H. pylori infection and gastric cancer, and supports eradicating H. pylori to prevent gastric cancer, say the researchers of the study published in the August 2 issue of the Lancet.

Read more: Eradicating H. pylori Reduces Risk for Gastric Cancer Recurrence

Urologic Disease Burden Among Veterans Underestimated

In the Veterans Affairs Healthcare System, estimates of urologic disease prevalence among males and females based only on primary diagnosis will significantly underestimate the true disease burden, say researchers in Los Angeles.

Read more: Urologic Disease Burden Among Veterans Underestimated

Risk of Infection, Death From MRSA Persists in Long-Term Carriers

People who harbor methicillin-resistant Staphylococcus aureus (MRSA) for more than 1 year remain at substantial risk of MRSA-related illness or death, according to a single-center retrospective cohort study published in the July 15 issue of Clinical Infectious Diseases.

Read more: Risk of Infection, Death From MRSA Persists in Long-Term Carriers

Disease-Free Period Predicts Response to Salvage Therapy for Oral Cancer

In patients with locally recurrent carcinomas of the oral cavity and oropharynx, a disease-free interval of more than 1 year and tumor tissue negative for EGFR (epidermal growth factor receptor) expression predict a good response to salvage surgery.

Read more: Disease-Free Period Predicts Response to Salvage Therapy for Oral Cancer

SIDS Linked to Early Atherosclerosis

Sudden infant death syndrome (SIDS) appears to be associated with early atherosclerotic lesions, according to a study presented on Sunday at the Argentine Congress of Cardiology. However, the mechanism of the association is unclear, the researchers said.

Read more: SIDS Linked to Early Atherosclerosis

Strontium Reduces Postmenopausal Nonvertebral and Vertebral Fracture Risk

Long-term strontium ranelate treatment reduces the risk of nonvertebral and vertebral fractures in women with postmenopausal osteoporosis, according to a report in the June issue of Arthritis & Rheumatism.

Read more: Strontium Reduces Postmenopausal Nonvertebral and Vertebral Fracture Risk

Vancomycin Underdosing Very Common in the Obese

More than 70% of obese patients do not receive adequate doses of vancomycin, possibly resulting in subtherapeutic concentrations, according to Dallas-based researchers. Criteria that are more stringent suggest that this may also be true of a much wider group of patients.

In the June issue of the American Journal of Medicine, Dr. Ronald G. Hall II of Texas Tech University and colleagues note that although body weight is the preferred method of calculating vancomycin dosage, many studies continue to use a flat dosing regimen of 1 g every 12 hours to evaluate new agents for the treatment of gram-positive infections, including methicillin-resistant Staphylococcus aureus.

Read more: Vancomycin Underdosing Very Common in the Obese

Growth Hormone Therapy May Decrease Diabetes Risk in Girls With Turner Syndrome

Growth hormone (GH) treatment has beneficial effects on body composition, regional fat deposition and glucose tolerance in girls with Turner syndrome, a study suggests.

"We found that GH-treated girls were leaner, with less abdominal fat and normal glucose tolerance compared with never-treated girls in the current study and compared with Turner syndrome girls in studies before the era of GH treatment," the study team reports in the June issue of the Journal of Clinical Endocrinology and Metabolism.

Read more: Growth Hormone Therapy May Decrease Diabetes Risk in Girls With Turner Syndrome

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